B4: Regulation of cell adhesion, trafficking, and lymphoid tissue formation by SWAP-70

Project leader: Prof. Dr. R. Jessberger

Formation of lymphoid tissue by hematopoietic precursor cells involves incompletely understood developmental programs, migration, adhesion and homing and their underlying mechanisms like cytoskeletal changes, cell polarization, chemokinesis, and integrin activity. SWAP-70 acts in some of these processes. We will now determine how and why lymphoid tissue structures depend on SWAP-70, how SWAP-70 molecularly controls F-actin rearrangements and integrin activity, how SWAP-70 itself is regulated, and how proper differentiation of the hematopoietic stem cell compartment depends on SWAP-70.