B7: The impact of microRNAs (miRNAs) on homing and mobilization of hematopoietic progenitor cells

Project leaders: Dr. T. Illmer, Prof. Dr. G. Ehninger

Hematopoietic progenitor cells interact with bone marrow derived stromal cells (BMSC) via CXCL12/CXCR4 signaling thus determining their stemness or proliferation fate. The regulatory potential of miRNAs on this axis and their effects on homing and mobilization will be analzed. The impact of individual miRNAs on the establishment of hematopoiesis will be studied in the zebrafish model to better understand the organisation of the hematopoietic niche. Finally, genetic variants that may influence the individual CXCL12/CXCR4 homeostasis will be investigated in healthy donors and patients.