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Gemeinsame Publikationen

Die Publikationen der einzelnen Teilprojekte entnehmen Sie bitte den projektbezogenen Publikationslisten.

A1 & A15

  • Zhang, D. J., Wang, Q., Wei, J., Baimukanova, G., Buchholz, F., Stewart, A. F., Mao, X., and Killeen, N. Selective expression of the Cre recombinase in late-stage thymocytes using the distal promoter of the Lck gene. J Immunol (2005) 174, 6725-6731.
  • Ennifar, E., Meyer, J. E., Buchholz, F., Stewart, A. F., and Suck, D. Crystal structure of a wild-type Cre recombinase-loxP synapse reveals a novel spacer conformation suggesting an alternative mechanism for DNA cleavage activation. Nucleic Acids Res (2003) 31 , 5449-5460.
  • Shimshek, D. R., Kim, J., Hubner, M. R., Spergel, D. J., Buchholz, F., Casanova, E., Stewart, A. F., Seeburg, P. H., and Sprengel, R. Codon-improved Cre recombinase (iCre) expression in the mouse. Genesis (2002) 32, 19-26.
  • Buchholz, F. and Stewart, A.F.: Alteration of Cre recombinase site specificity by sub-strate-linked protein evolution. Nature Biotechnology (2001) 19, 1047-52.
  • Muyrers, J.P.P., Zhang, Y., Buchholz, F. and Stewart, A.F.: RecE/RecT and Red?/Red? initiate double stranded break repair by specifically interacting with their re-spective partners. Genes and Development (2000), 14, 1971-1982.
  • Rodriguez, C. I., Buchholz, F., Galloway, J., Sequerra, R., Kasper, J., Ayala, R., Stewart, A. F., and Dymecki, S. M. High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet (2000) 25, 139-140.
  • Zhang, Y., Buchholz, F., Muyrers, J.P.P. and Stewart, A.F.: A new logic for DNA en-gineering using recombination in E. coli. Nature Genetics (1998), 20, 123-128.*
  • Ringrose, L., Lounnas, V., Ehrlich, L., Buchholz, F., Wade, R., and Stewart, A. F. Comparative kinetic analysis of FLP and cre recombinases: mathematical models for DNA binding and recombination. J Mol Biol (1998) 284, 363-384.
  • Angrand, P.O., Woodroofe, C. P., Buchholz, F., and Stewart, A. F. Inducible expression based on regulated recombination: a single vector strategy for stable expression in cultured cells. Nucleic Acids Res (1998) 26, 3263-3269.
  • Buchholz, F., Angrand, P. O., and Stewart, A. F. Improved properties of FLP recombinase evolved by cycling mutagenesis. Nat Biotechnol (1998) 16, 657-662.
  • Buchholz, F., Ringrose, L., Angrand, P. O., Rossi, F., and Stewart, A. F. Different thermostabilities of FLP and Cre recombinases: implications for applied site-specific recombination. Nucleic Acids Res (1996) 24, 4256-4262.
  • Buchholz, F., Angrand, P. O., and Stewart, A. F. A simple assay to determine the functionality of Cre or FLP recombination targets in genomic manipulation constructs. Nucleic Acids Res (1996) 24, 3118-3119.

A2 & A3

  • Huttner, W.B. and Brand, M. Asymmetric division and polarity of neuroepithelial cells. Curr. Opin. Neurobiol. (1997) 7, 29-39.

A2 & A13

  • Jászai, J., P. Janich, L.M. Farkas, C.A. Fargeas, W.B. Huttner and D. Corbeil. 2007. Differential expression of Prominin-1 (CD133) and Prominin-2 in major cephalic exocrine glands of adult mice. Histochem Cell Biol. In press

  • Lardon, J., D. Corbeil, W.B. Huttner, Z. Ling and L. Bouwens. 2007. Stem cell marker prominin 1/AC133 is expressed in duct cells of the adult human pancreas. Pancreas. In press

  • Fargeas CA, Huttner WB and Corbeil D. Nomenclature of prominin-1 (CD133) splice variants – An update. Tissue Antigens. (2007) 69: 602-606.

  • Dubreuil D. Marzesco A.-M, Corbeil D, Huttner WB and Wilsch-Bräuninger M. Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1. J. Cell Biol. (2007) 176: 483-495.

  • Fargeas CA, Fonseca A-V, Huttner WB and Corbeil D. Prominin-1 (CD133) – from progenitor cells to human diseases. Future Lipidology. (2006) 1: 213-225.

  • Jaszai J, Fargeas CA, Florek M, Huttner WB, Corbeil D. Focus on Molecules: Prominin-1 (CD133). Exp Eye Res. (2006) May 27 [Epub ahead of print]

  • Marzesco AM, Janich P, Wilsch-Brauninger M, Dubreuil V, Langenfeld K, Corbeil D, Huttner WB. Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells. J Cell Sci. (2005) 118: 2849-2858.

  • Kania G, Corbeil D, Fuchs J, Tarasov KV, Blyszczuk P, Huttner WB, Boheler KR, Wobus AM. Somatic stem cell marker prominin-1/CD133 is expressed in embryonic stem cell-derived progenitors. Stem Cells. (2005) Jun-Jul;23(6):791-804.

  • Lee A, Kessler JD, Read TA, Kaiser C, Corbeil D, Huttner WB, Johnson JE, Wechsler-Reya RJ. Isolation of neural stem cells from the postnatal cerebellum. Nature Neurosci. (2005) 8: 723-9. Epub 2005 May 22.
  • Kania, G., Corbeil, D., Tarasov, K.V., Blyszczuk, P., Huttner, W.B., Boheler, K.R. and Wobus, A.M. The somatic stem cell marker prominin-1/CD133 is expressed in embryonic stem cell-derived progenitors. Stem Cells (2005) 23, 791-804.
  • Lee A. Kessler J.D, Read T.A, Kaiser, C., Corbeil, D., Huttner, W.B., Johnson, J.E. and Wechsler-Reya, R.J. Isolation of neural stem cells from the postnatal cerebellum. Online Nature Neuroscience (2005) 8, 723-29.
  • Kania, G., Corbeil, D., Tarasov, K.V., Blyszczuk, P., Huttner, W.B., Boheler, K.R. and Wobus, A.M. The somatic stem cell marker prominin-1/CD133 is expressed in embryonic stem cell-derived progenitors. Stem Cells (2005) 23, 791-804.
  • Lee A. Kessler J.D, Read T.A, Kaiser, C., Corbeil, D., Huttner, W.B., Johnson, J.E. and Wechsler-Reya, R.J. Isolation of neural stem cells from the postnatal cerebellum. Online Nature Neuroscience (2005) 8, 723-29.
  • Fargeas, C.A., Joester, A., Missol-Kolka, E., Hellwig, A., Huttner, W.B. and Corbeil, D. Identification of novel Prominin-1/CD133 splice variants with alternative C-termini and their expression in epididymis and testis. J. Cell Sci. (2004), 117, 4301-4311.
  • Kosodo, Y., Röper, K., Haubensak, W., Marzesco, A.-M., Corbeil, D. and Huttner, W.B. Asymmetric distribution of the apical plasma membrane during neurogenic divisions of mammalian neuroepithelial cells. EMBO J. (2004) 23, 2314-2324.
  • Fargeas, C.A., Corbeil, D. and Huttner, W.B. AC133 Antigen, CD133, Prominin-1, Prominin-2., Etc.: Prominin family gene products in need of a rational nomenclature. Stem Cells (2003) 21, 506-508.
  • Fargeas, C.A., Florek, M., Huttner, W.B. and Corbeil, D. Characterization of prominin-2, a new member of the prominin family of pentaspan membrane glycoproteins. J. Biol. Chem. (2003) 278, 8585-8596.
  • Corbeil, D., Fargeas, C.A. and Huttner, W.B. Rat prominin, like its mouse and human orthologues, is a pentaspan membrane glycoprotein. Biochem. Biophys. Res. Commun. (2001) 285, 939-944.
  • Corbeil, D., Röper, K., Fargeas, C.A., Joester, A and Huttner, W.B. Prominin: a story of cholesterol, plasma membrane protrusions, and human pathology. Traffic (2001) 2, 82-91.
  • Röper, K., Corbeil, D. and Huttner, W.B. Retention of prominin in microvilli reveals distinct cholesterol-based lipid microdomains in the apical plasma membrane. Nature Cell Biol. (2000) 2, 582-592.
  • Corbeil, D., Röper, K., Hellwig, A., Tavian, M., Miraglia, S., Watt, S.M., Simmons, P.J., Peault, B., Buck, D.W. and Huttner, W.B. The human AC133 hematopoietic stem cell antigen is also expressed in epithelial cells and targeted to plasma membrane protrusions. J. Biol. Chem. (2000) 275, 5512-5520.
  • Röper, K., D. Corbeil and W.B. Huttner. Distinct lipid microdomains within the apical plasma membrane of polarized epithelial cells. A potential role of the lipid bilayer in the retention of prominin in microvilli. In Protein, Lipid and Membrane Traffic: Pathway and Targeting. Edited by Jos A.F. Op den Kamp. IOS Press. NATO Science Series. (2000) Vol. 322: 73-84.
  • Maw, M., Corbeil, D., Koch, J., Hellwig, A., Wilson-Wheeler, J.C., Bridges, R.J., Kumaramanickavel, G., John, S., Nancarrow, D., Röper, K., Weigmann, A., Huttner, W.B. and Denton, M.J. A frameshift mutation in prominin (mouse)-like 1 causes human retinal degeneration. Human Molecular Genetics (2000) 9, 27-34.
  • Corbeil, D., Röper, K., Hannah, M.J., Hellwig, A. and Huttner, W.B. Selective localization of the polytopic membrane protein prominin in microvilli of epithelial cells - a combination of apical sorting and retention in plasma membrane protrusions. J. Cell Sci. (1999) 112, 1023-1033.
  • Weigmann, A., Corbeil, D., Hellwig, A. and Huttner, W.B. Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells. Proc. Natl. Acad. Sci. USA (1997) 94, 12425-12430.

A2 & A15

  • Buchholz, F., Calegari, F., Kittler, R. and Huttner, W.B. Bookchapter: RNA interference in post-implantation mouse embryos. In: RNA Interference: From Basic Biology to Drug Development; K. Appasani, ed.; Cambridge University Press. March (2005), pp. 207-19.
  • Calegari, F., Marzesco, A.M., Kittler, R., Buchholz, F. and Huttner, W.B. Tissue-specific RNA interference in post-implantation mouse embryos using directional electroporation and whole embryo culture. Differentiation (2004) 72, 92-102.
  • Calegari, F., Haubensak, W., Yang, D., Huttner, W.B. and Buchholz, F. Tissue-specific RNA interference in postimplantation mouse embryos with endoribonuclease-prepared short interfering RNA. Proc. Natl. Acad. Sci. USA (2002) 99, 14236-14240.

A2 & A13 & A17

  • Florek M, Bauer N, Janich P, Wilsch-Braeuninger M, Fargeas CA, Marzesco A-M, Thiele C, Ehninger G, Huttner WB and Corbeil D. Prominin-2 is a cholesterol-binding protein associated with apical and basolateral plasmalemmal protrusions in polarized epithelial cells and released into the urine. Cell Tissue Res. (2007) 328: 31-47.

  • Florek, M., Haase, M., Marzesco, A.-M., Freund, D., Ehninger, G., Huttner, W.B. and Corbeil, D. Prominin-1/CD133, a neural and hematopoietic stem cell marker, is expressed in adult human differentiated cells and certain types of kidney cancer. Cell Tissue Res.(2005) 319, 15-26.

A6 & A13

  • Sicard F, Ehrhart-Bornstein M, Corbeil D, Sperber S, Krug AW, Ziegler CG, Rettori V, McCann SM, Bornstein SR: Growth factors, DHEA and DHEAS regulate chromaffin cells proliferation in an age-dependent manner. Proc Natl Acad Sci U S A (2007) 104: 2007-2012.

A12 & A13

  • Bauer, N., A.-V. Fonseca, M. Florek, D. Freund, J. Jászai, M. Bornhäuser, C.A. Fargeas and D. Corbeil. 2007. New insights into the cell biology of hematopoietic progenitors by studying prominin-1 (CD133). Cells Tissues Organs. In press

A12 & A16

  • Bornhäuser M, Thiede C.: Chimerism analysis after allogeneic stem cell transplantation. Haematologica. (2005) Oct;90(10):1301A.

A12 & A17

  • Bornhauser,M., Kroger,N., Schwerdfeger,R., Schafer-Eckart,K., Sayer,H.G., Scheid,C., Stelljes,M., Kienast,J., Mundhenk,P., Fruehauf,S., Kiehl,M.G., Wandt,H., Theuser,C., Ehninger,G., Zander,A.R.: Allogeneic haematopoietic cell transplantation for chronic myelogenous leukaemia in the era of imatinib: a retrospective multicentre study. European Journal of Haematology (2006) 76, 9-17.
  • Babatz J, Rollig C, Lobel B, Folprecht G, Haack M, Gunther H, Kohne CH, Ehninger G, Schmitz M, Bornhäuser M.: Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. Cancer Immunol Immunother. (2006) Mar;55(3):268-76.
  • Kroschinsky F, Holig K, Poppe-Thiede K, Zimmer K, Ordemann R, Blechschmidt M, Oelschlaegel U, Bornhäuser M, Rall G, Rutt C, Ehninger G.: Single-dose pegfilgrastim for the mobilization of allogeneic CD34+ peripheral blood progenitor cells in healthy family and unrelated donors. Haematologica. (2005) Dec;90(12):1665-71.
  • Stelljes M, Bornhäuser M, Kroger M, Beyer J, Sauerland MC, Heinecke A, Berning B, Scheffold C, Silling G, Buchner T, Neubauer A, Fauser AA, Ehninger G, Berdel WE, Kienast J; Cooperative German Transplant Study Group.: Conditioning with 8-Gy total body irradiation and fludarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia. Blood. (2005) Nov 1;106(9):3314-21.
  • Platzbecker U, Bornhäuser M, Zimmer K, Lerche L, Rutt C, Ehninger G, Holig K.: Second donation of granulocyte-colony-stimulating factor-mobilized peripheral blood progenitor cells: risk factors associated with a low yield of CD34+ cells. Transfusion. (2005) Jan;45(1):11-5.
  • Stelljes,M., Bornhäuser,M., Kröger,M., Beyer,J., Sauerland,M.C., Heinecke,A., Berning,B., Scheffold,C., Silling, G.; Buchner, T.; Neubauer, A.; Fauser, A.A; Ehninger,G., Berdel,W.E., Kienast,J. Conditioning with 8 Gy total body irradiation and fludarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia. Blood 106, (2005), 3314-3321.
  • Schetelig,J., Kiani,A., Schmitz,M., Ehninger,G., Bornhauser,M.: T cell-mediated graft-versus-leukemia reactions after allogeneic stem cell transplantation. Cancer Immunology Immunotherapy (2005) 54, 1043-1058.
  • Schirutschke,H., Bornhauser,M., Oelschlagel,U., Schmidt,C., Gretzinger,S., Babatz,J., Ehninger,G., Holig,K., Platzbecker,U.: Changes in expression of effector molecules on T- and NK-cells in healthy donors of PBSC in response to G-CSF. Bone Marrow Transplantation (2005) 35, S64.
  • Holig,C., Kabus,B., Ehninger,G., Bornhauser,M., Illmer,T.: Clinical efficiency of granulocyte transfusions from healthy related donors mobilised with G-CSF and dexamethasone. Bone Marrow (2005)
  • Schetelig,J., Breitschaft,A., Kroger,N., Zabelina,T., Ebell,W., Bornhauser,M., Haack,A., Ehninger,G., Salama,A., Siegert,W.: After major ABO-mismatched allogeneic hematopoietic progenitor cell transplantation, erythroid engraftment occurs later in patients with donor blood group A than donor blood group B. Transfusion (2005) 45, 779-787.
  • Jenke,A., Freiberg-Richter,J., Wilhelm,S., Freund,M., Renner,U.D., Bornhauser,M., Schleyer,E., Ehninger,G., Schuler,U. : Accidental busulfan overdose during conditioning for stem cell transplantation. Bone Marrow Transplantation (2005) 35, 125-128.
  • Berndt,A., Helwig,A., Ehninger,G., Bornhauser,M.: Successful transplantation of CD34+ selected peripheral blood stem cells from an unrelated donor in an adult patient with Diamond-Blackfan anemia and secondary hemochromatosis. Bone Marrow Transplantation (2005) 35, 99-100.
  • Oswald,J., Boxberger,S., Jorgensen,B., Feldmann,S., Ehninger,G., Bornhäuser,M., and Werner,C. Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells 22, (2004), 377-384.
  • Oswald,J., Jorgensen,B., Pompe,T., Kobe,F., Salchert,K., Bornhäuser,M., Ehninger,G., and Werner,C. Comparison of flow cytometry and laser scanning cytometry for the analysis of CD34+ hematopoietic stem cells. Cytometry 57A, (2004), 100-107.
  • Ehninger,G., Rall,G., Kroschinsky,F., Schuler,U.S., Schmidt,A., Hoelig,K., Bornhaeuser,M., Rutt,C.: Long-term follow-up of 5,930 unrelated volunteers donating bone marrow or peripheral blood stem cells. Blood (2004) 104, 753A-754A.
  • Kiehl,M.G., Kraut,L., Schwerdtfeger,R., Hertenstein,B., Remberger,M., Kroeger,N., Stelljes,M., Bornhaeuser,M., Martin,H., Scheid,C., Ganser,A., Zander,A.R., Kienast,J., Ehninger,G., Hoelzer,D., Diehl,V., Fauser,A.A., Ringden,O.: Outcome of allogeneic hematopoietic stem-cell transplantation in adult patients with acute lymphoblastic leukemia: No difference in related compared with unrelated transplant in first complete remission. Journal of Clinical Oncology (2004) 22, 2816-2825.
  • Oswald,J., Boxberger,S., Jorgensen,B., Feldmann,S., Ehninger,G., Bornhauser,M., Werner,C.: Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells (2004) 22, 377-384.
  • Bornhäuser,M., Platzbecker,U., Theuser,C., Hölig,K., Ehninger,G.: CD34+-enriched peripheral blood progenitor cells from unrelated donors for allografting of adult patients: high risk of graft failure, infection and relapse despite donor lymphocyte add-back. Br J Haematol (2002) 118, 1095 -103.
  • Bornhäuser,M., Kiehl,M., Siegert,W., Schetelig,J., Hertenstein,B., Martin,H., Schwerdtfeger,R., Sayer,H.G., Runde,V., Kröger,N., Theuser,C., Ehninger,G.: Dose-reduced conditioning for allografting in 44 patients with chronic myeloid leukaemia: a retrospective analysis. Br J Haematol (2001) 115, 119–24.
  • Ringden,O., Remberger,M., Runde,V., Bornhauser,M., Blau,I.W., Basara,N., Holig,K., Beelen,D.W., Hagglund,H., Basu,O., Ehninger,G., Fauser,AA.: Peripheral blood stem cell transplantation from unrelated donors: a comparison with marrow transplantation. Blood (1999) 94, 455-464.
  • Kohler,T., Plettig,R., Wetzstein,W., Schaffer,B., Ordemann,R., Nagels,H.O., Ehninger,G., and Bornhäuser,M. Defining optimum conditions for the ex vivo expansion of human umbilical cord blood cells. Influences of progenitor enrichment, interference with feeder layers, early-acting cytokines and agitation of culture vessels. Stem Cells 17, ,(1999), 19-24.

A12 & A13 & A17

  • Freund D, Bauer N, Boxberger S, Jørgensen B, Feldmann S, Streller U, Ehninger G, Werner C, Bornhäuser M, Oswald J and Corbeil D. Polarization of human hematopoietic progenitors during contact with multipotent mesenchymal stromal cells – effects on proliferation and clonogenicity. Stem Cells Dev. (2006) 15: 815-829.

  • Freund D, Oswald J, Feldmann S, Ehninger G, Corbeil D, Bornhäuser M. : Comparative analysis of proliferative potential and clonogenicity of MACS-immunomagnetic isolated CD34+ and CD133+ blood stem cells derived from a single donor. Cell Prolif. (2006) 39: 325-32.

  • Bauer,N., Fonseca,A.V., Freund,D., Boxberger,S., Oswald,J., Werner C, Ehninger G, Bornhaeuser M, Corbeil D: Cellular and molecular events underlying the interaction of hematopoietic stem and progenitor cells with mesenchymal stem cells. Blood (2005) 106, 650A.

A12 & A16 & A17

  • Bornhauser,M., Thiede,C., Babatz,J., Schetelig,J., Illmer,T., Kiani,A., Platzbecker,U., Herr,W., Rieber,E.P., Ehninger,G., & Schmitz,M. Infusion of bcr/abl peptide-reactive donor T cells to achieve molecular remission of chronic myeloid leukemia after CD34(+) selected allogeneic hematopoietic cell transplantation. Leukemia (2006), 20, 2055-2057.
  • Auffermann-Gretzinger,S., Eger,L., Bornhauser,M., Schakel,K., Oelschlaegel,U., Schaich,M., Illmer,T., Thiede,C., & Ehninger,G. Fast appearance of donor dendritic cells in human skin: dynamics of skin and blood dendritic cells after allogeneic hematopoietic cell transplantation. Transplantation (2006), 81, 866-873.
  • Oswald J, Steudel C, Salchert K, Joergensen B, Thiede C, Ehninger G, Werner C, Bornhäuser M.: Gene-expression profiling of CD34+ hematopoietic cells expanded in a collagen I matrix. Stem Cells. (2006) Mar;24(3):494-500.
  • Strodtbeck,D., Bornhauser,M., Hanel,M., Lerche,L., Schaich,M., Illmer,T., Thiede,C., Geissler,G., Herbst,R., Ehninger,G., Platzbecker,U.: Graft clonogenicity and intensity of pre-treatment: factors affecting outcome of autologous peripheral hematopoietic cell transplantation in patients with acute myeloid leukemia in first remission. Bone Marrow Transplantation (2005) 36, 1083-1088.
  • Kiani,A., Habermann,I., Haase,M., Feldmann,S., Boxberger,S., Sanchez-Fernandez,M.A., Thiede,C., Bornhäuser,M., and Ehninger,G.. Expression and regulation of NFAT (nuclear factors of activated T cells) in human CD34+ cells: down-regulation upon myeloid differentiation. J. Leukoc. Biol. 5, (2004), 1057-1065.
  • Mohr,B., Koch,R., Thiede,C., Kroschinsky,F., Ehninger,G., Bornhauser,M.: CD34+ cell dose, conditioning regimen and prior chemotherapy: factors with significant impact on the early kinetics of donor chimerism after allogeneic hematopoietic cell transplantation. Bone Marrow Transplantation (2004) 34, 949-954.
  • Thiede,C., Bornhauser,M., Ehninger,G.: Strategies and clinical implications of chimerism diagnostics after allogeneic hematopoietic stem cell transplantation. Acta Haematologica (2004) 112, 16-23.
  • Thiede,C., Steudel,C., Mohr,B., Schaich,M., Schakel,U., Platzbecker,U., Wermke,M., Bornhauser,M., Ritter,M., Neubauer,A., Ehninger,G., & Illmer,T. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood (2002), 99, 4326-4335.
  • Thiede,C., Bornhäuser,M., Oelschlägel,U., Brendel,C., Leo,R., Daxberger,H., Mohr,B., Florek,M., Kroschinsky,F., Geissler,G., Naumann,R., Ritter,M., Prange-Krex,G., Lion,T., Neubauer,A., Ehninger,G.: Sequential monitoring of chimerism and detection of minimal residual disease after allogeneic blood stem cell transplantation (BSCT) using multiplex PCR amplification of short tandem repeat-markers. Leukemia (2001) 15, 293 –302.
  • Bornhäuser,M., Thiede,C., Platzbecker,U., Jenke,A., Helwig,A., Plettig,R., Freiberg-Richter,J., Röllig,C., Geissler,G., Lutterbeck,K., Oelschlägel,U., Ehninger,G.: Dose-reduced conditioning and allogeneic hematopoietic stem cell transplantation from unrelated donors in 42 patients. Clin Cancer Res (2001) 7, 2254 –62.
  • Platzbecker,U., Thiede,C., Freiberg-Richter,J., Röllig,C., Helwig,A., Schäkel,U., Mohr,B., Schaich,M., Ehninger,G., Bornhäuser,M.: Early allogeneic blood stem cell transplantation after modified conditioning therapy during marrow aplasia: stable remission in high-risk acute myeloid leukemia. Bone Marrow Transplant (2001) 27, 543 –6.
  • Bornhäuser,M., Thiede,C., Brendel,C., Geissler,G., Oelschlägel,U., Neubauer,A., Ehninger,G.: Stable engraftment after megadose blood stem cell transplantation across the HLA barrier: the case for natural killer cells as graft-facilitating cells. Transplantation (1999) 68, 87-88.
  • Thiede,C., Florek,M., Bornhauser,M., Ritter,M., Mohr,B., Brendel,C., Ehninger,G., Neubauer,A.: Rapid quantification of mixed chimerism using multiplex amplification of short tandem repeat markers and fluorescence detection. Bone Marrow Transplant (1999) 23, 1055-1060.

A12 & A13 & A16 & A17

  • Bornhäuser,M., Eger,L., Oelschlaegel,U., Auffermann-Gretzinger,S., Kiani,A., Schetelig,J., Illmer,T., Schaich,M., Corbeil,D., Thiede,C., and Ehninger,G.. Rapid reconstitution of dendritic cells after allogeneic transplantation of CD133(+) selected hematopoietic stem cells. Leukemia 19, (2005), 161–165.

A16 & A17

  • Thiede,C., Creutzig,E., Illmer,T., Schaich,M., Heise,V., Ehninger,G., & Landt,O. Rapid and sensitive typing of NPM1 mutations using LNA-mediated PCR clamping. Leukemia (2006), 20, 1897-1899.
  • Platzbecker,U., Germing,U., Schakel,U., Illmer,T., Soucek,S., Schaich,M., Ehninger,G., & Thiede,C. Association with the single-nucleotide polymorphism (Glu785Lys) of the granulocyte colony-stimulating factor receptor with myelodysplastic syndromes and acute myeloid leukemia with multlineage dysplasia. Leukemia (2006).
  • Thiede,C., Koch,S., Creutzig,E., Steudel,C., Illmer,T., Schaich,M., & Ehninger,G. Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood (2006), 107, 4011-4020.
  • Ritter,M., Kattmann,D., Teichler,S., Hartmann,O., Samuelsson,M.K., Burchert,A., Bach,J.P., Kim,T.D., Berwanger,B., Thiede,C., Jager,R., Ehninger,G., Schafer,H., Ueki,N., Hayman,M.J., Eilers,M., & Neubauer,A. Inhibition of retinoic acid receptor signaling by Ski in acute myeloid leukemia. Leukemia (2006), 20, 437-443.
  • Baldus,C.D., Thiede,C., Soucek,S., Bloomfield,C.D., Thiel,E., & Ehninger,G. BAALC expression and FLT3 internal tandem duplication mutations in acute myeloid leukemia patients with normal cytogenetics: prognostic implications. J.Clin. Oncol. (2006), 24, 790-797.
  • Trautmann,K., Steudel,C., Grossmann,D., Aust,D., Ehninger,G., Miehlke,S., & Thiede,C. Expression profiling of gastric cancer samples by oligonucleotide microarray analysis reveals low degree of intra-tumor variability. World J.Gastroenterol. (2005), 11, 5993-5996.
  • Illmer,T., Thiede,C., Fredersdorf,A., Stadler,S., Neubauer,A., Ehninger,G., & Schaich,M. Activation of the RAS pathway is predictive for a chemosensitive phenotype of acute myelogenous leukemia blasts. Clin.Cancer Res. (2005), 11, 3217-3224.
  • Thiede,C., Koch,S., Creutzig,E., Steudel,C., Illmer,T., Schaich,M., Ehninger,G.: Mutations of the nucleophosmin (NPM1) gene are common in adult acute myeloid leukemia and associated with favorable prognosis if present without FLT3-ITD mutation. Blood (2005) 106, 69A.
  • Steudel,C., Wermke,M., Schaich,M., Schakel,U., Illmer,T., Ehninger,G., & Thiede,C. Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemia. Genes Chromosomes Cancer (2003), 37, 237-251.
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