A7: SFB-relevante Publikationen

Projektleitung: Prof. Dr. M. Solimena

• Borgonovo B, Ouwendijk J, Solimena M. 2006. Biogenesis of secretory granules. Curr. Opin. Cell Biol. 18: 365-370.
• Trajkovski M, Mziaut H, Schwarz PE, Solimena M. 2006. Genes of type 2 diabetes in beta cells. Endocrinol. Metab. Clin. North. Am. 35: 357-369.
• Mziaut H, Trajkovski M, Kersting S, Ehninger A, Altkruger A, Lemaitre RP, Schmidt D, Saeger HD, Lee MS, Drechsel DN, Muller S, Solimena M. 2006. Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5. Nat. Cell Biol. 8: 435-445.
• Knoch KP, Meisterfeld R, Kersting S, Bergert H, Altkrüger A, Wegbrod C, Jäger M, Saeger HD, Solimena M. 2006. cAMP-dependent phosphorylation of PTB1 promotes the expression of insulin secretory granule proteins in beta cells. Cell Metab. 3: 123-134.
• Bergert H, Knoch K-P, Meisterfeld R, Jäger M, Ouwendijk J, Kersting S, Saeger H-D, Solimena M. 2005. Effect of oxygenated perfluorocarbons on isolated rat pancreatic islets in culture. Cell Transplant. 14: 1-8.
• Shin H, Hayashi M, Christoforidis S, Lacas-Gervais S, Hoepfner S, Wenk M, Modregger J, Uttenweiler-Joseph S, Wilm M, Nystuen A, Frankel W, Solimena M, De Camilli P, and Zerial M. 2005. An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway. J. Cell. Biol. 170: 607-618.
• Murinson BB, Butler M, Marfurt K, Gleason S, De Camilli P, Solimena M. Markedly elevated GAD antibodies in SPS: effects of age and illness duration. Neurology. 2004 Dec 14;63(11):2146-8 (editorial).
• Trajkovski M, Mziaut H, Altkrüger A, Ouwendijk J, Knoch K-P, Müller S, Solimena M. 2004. Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in ß-cells J. Cell Biol. 167: 1063-1074.
• Lacas-Gervais S, Guo J, Strenzke N, Scarfone E, Kolpe M, De Camilli P, Moser T, Rasband M, Solimena M. 2004. bIVS1 spectrin stabilizes nodes of Ranvier and axon initial segments. J. Cell Biol. 166: 983-990
• Yang Y, Lacas-Gervais S, Morest KD, Solimena M, Rasband MN. 2004. ßIV spectrins are essential for membrane stability and the molecular organization of nodes of Ranvier. J. Neurosci. 24: 9230-9240.
• Knoch KP, Bergert H, Borgonovo B, Saeger HD, Altkrüger A, Verkade P, Solimena M. 2004 Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis. Nat. Cell Biol. 6: 207-214.
• Petzold GC, Marcucci M, Butler MH, van Landeghem FKH, Scholz P, Einhäupl KM, Solimena M, Valdueza JM, De Camilli P. 2004 Rhabdomyolysis and paraneoplastic stiff-man syndrome with amphiphysin autoimmunity. Ann. Neurol. 55: 286-290.
• Solimena M and Gerdes H-H. 2003. And the last shall be the first… Trends Cell Biol. 13: 399-402.
• Spitzenberger F, Pietropaolo S, Verkade P, Habermann B, Lacas-Gervais S, Mziaut H, Pietropaolo M, and Solimena M. 2003. ICA69 is an arfaptin-related protein associated with the Golgi complex and immature secretory granules of insulinoma INS-1 cells. J. Biol. Chem: 278: 26166-26173.
• Schmierer K, Grosse P, De Camilli P, Solimena M, Floyd S, Zschenderlein R 2002. Paraneoplastic stiff-person syndrome-no tumor progression over five years. Neurology 58: 148.
• Ort T, Voronov S, Guo J, Zawalich K, Froehner S, Zawalich W, Solimena M. 2001. Dephosphorylation of b2-syntrophin and Ca2+/calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion. EMBO J 20: 4013-4023.
• Berghs S, Ferracci F, Maksimova E, Gleason S, Leszczynski N, Butler M, De Camilli P, Solimena M. 2001. Autoimmunity to bIV spectrin in paraneoplastic lower motor neuron syndrome. PNAS USA 98: 6945-6950.
• Meinck H-M, Maile S, Faber L, Morgenthaler N, Seissler J, Butler M, Solimena M, DeCamilli P, Scherbaum WA. 2001. Antibodies against glutamic acid decarboxylase (GAD)- prevalence in neurological diseases. J. Neurol. Neurosurg. Psych. 71: 100-103.
• Solimena M, and De Camilli P. 2000. Synaptic autoimmunity and the Salk factor. Neuron 28: 309-310.
• Berghs S, Aggujaro D, Dirkx R, Stabach P, Hermel J-H, Maksimova E, Zhang J-P, Philbrick W, Slepnev V, Ort T, Solimena M. 2000. bIV spectrin, a new spectrin localized at axon initial segments and nodes of Ranvier in the central and peripheral nervous system. J. Cell Biol. 27: 985-1002.
• Solimena M, Butler M, De Camilli P. 2000. Autoimmunity in Stiff-Man syndrome. 2000. In: "Autoantigens, Autoantibodies, Autoimmunity". K. Conrad, ed, Lengerich: Pabst Science Publishers, pp. 601-610.
• Ort T, Maksimova E, Dirkx R, Kachinsky A, Berghs S, Froehner S, Solimena M. 2000. The receptor tyrosine phoshatase like-protein ICA512 binds the PDZ domains of b2-syntrophin and nNOS in pancreatic ß-cells. Eur. J. Cell Biol. 79, 621-630.
• Butler MH, Hayashi A, Ohkoshi N, C. Villmann, C.-M. Becker, Feng G, De Camilli P, Solimena M. 2000. Autoimmunity to gephyrin in Stiff-Man Syndrome. Neuron 26: 307-312.
• Ferracci F, Fassetta G, Butler, MH, Floyd S, Solimena M, De Camilli P. 1999. Autoantibodies to axon initial segments and nodes of Ranvier in a case of lower motor neuron disease associated with breast cancer. Neurology 53:852-855.
• Hermel J-M, Dirkx R, Solimena M. 1999. Post-translational modifications of ICA512, a receptor protein tyrosine phosphatase like-protein of secretory granules. Eur. J. Neurosci. 11: 2609-2620.
• Pugliese A, Kawasaki E, Zeller M, Yu L, Solimena M, Moraes C, Ricordi C, Erlich HA, Eisenbarth GS. 1999. Sequence analysis of the type I diabetes-protective HLA-DQB1*0602 and DQA1*0102 alleles in unaffected islet cell antibody-positive first degree relatives. J. Clin. Endocrinol. Metab. 84:1722-1728.
• Solimena M. 1998. Vesicular autoantigens of type I diabetes. 1998. Diabetes Metabolism Review 14: 227-240.
• Saginario C, Sterling D, Beckers C, Kobayashi R, Solimena M, Ullu E, Vignery A. 1998. MFR, a putative receptor mediating the fusion of macrophages. Mol. Cell Biol. 18: 6213-23.
• Schmierer K, Valdueza JM, Bender A, De Camilli P, David C, Solimena M, Zschenderlein R. 1998. Stiff-man syndrome with spinal MRI findings, amphiphysin autoantibodies and immunosuppressive treatment. Neurology 51: 250-252.
• Geng L, Solimena M, Flavell RA, Sherwin RS, Hayday H. 1998. Widespread expression of an autoantigen-GAD65 transgene does not tolerise NOD mice, and can exacerbate disease. PNAS USA 95: 10055-10060.
• Lee MS, Dirkx R, Solimena M, Dannies PS. 1998. Stabilization of the receptor protein tyrosine phosphatase like protein ICA512 in GH4C1 cells upon treatment with estradiol, insulin and EGF. Endocrinology 139: 2727-2733.
• Floyd S, Butler MH, Cremona O, David C, Freyberg Z, Zhang A, Solimena M, Tsutsui K, De Camilli P. 1998. Enhanced expression of amphiphysin in breast cancer. Mol. Medicine 4: 29-39.
• Zekzer D, Wong S, Ayalon O, Millet I, Altieri, M, Shintani, S, Solimena M, Sherwin, RS. 1998. GAD reactive CD4+ Th1 cells induces diabetes in NOD/SCID mice. J. Clin. Invest. 101: 68-73.
• Rosin L, De Camilli P, Butler M, Solimena M, Bastert G, Schmitt H-P, Morgenthaler N, Döderlein G, H-M Meinck. 1998. Stiff-man syndrome in a woman with breast cancer: an uncommom central nervous system paraneoplastic syndrome. Neurology 50: 94-98.
• Bult A, Zhao F, Dirkx R, Raghunathan A, Solimena M, Lombroso PJ. 1997. STEP: A family of brain enriched PTPs: alternative splicing produces transmembrane, cytosolic and truncated isoforms. Eur. J. Cell Biol. 72: 337-344.
• Khachatryan A, Guerder S, Palluault F, Cote G, Solimena M, Valentijn K, Millet I, Flavell RA, Vignery A. 1997. Targeted expression of the neuropeptide calcitonin gene related peptide to beta cells prevents diabetes in NOD mice. J. Immunol. 158: 1409-1416.
• Bult A, Zhao F, Dirkx R, Sharma E, Solimena M, Naegele JR, Lombroso PJ. 1996. STEP61: A member of a family of brain-enriched PTPs is localized to the endoplasmic reticulum. J. Neurosci. 16: 7821-31.
• Solimena M, De Camilli, P. 1996. From Th1 to Th2: diabetes immunotherapy shifts gears. Nature Med. 2: 1311-12.
• Solimena M, Dirkx R, Hermel J-M, Pleasic-Williams S, Shapiro JA, Rabin DU. 1996. The receptor-type phosphatase like protein ICA 512 is an ubiquitous intrinsic membrane protein of neuroendocrine secretory granules. EMBO J. 15: 2102-14.
• Meinck HM, Ricker K, Hulser R, Solimena M. 1995. Stiff-man syndrome: neurophysiological findings in eight patients. J. Neurol. 242: 134-42.
• Dirkx R, Thomas A, Li L, Lernmark Å, Sherwin R, De Camilli P, Solimena, M. 1995. Targeting of the 67 kd isoform of glutamic acid decarboxylase (GAD67) to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65 kd isoform of glutamic acid decarboxylase (GAD65). J. Biol. Chem. 270: 2241-2246.
• Solimena M, De Camilli. 1995. Coxsackieviruses and diabetes. Nature Med. 1: 25-26.
• Pugliese A, Eisenbarth GS, De Camilli P, Solimena M. 1994. Genetics of susceptibility and resistance to insulin-dependent diabetes mellitus in stiff-man syndrome. Lancet. 144: 1027-1028.
• David C, Solimena M, De Camilli P. 1994. Autoimmunity to Stiff-man syndrome with breast cancer is targeted to the C-terminal region of human amphiphysin, a protein homologous to the yeast proteinsRvs167 and Rvs161. FEBS Lett. 351: 73-9.
• Solimena M, Dirkx R, Radzynski M, Mundigl O, De Camilli P. 1994. A signal located within a.a. 1-27 of GAD65 is responsible for its targeting to the Golgi complex region. J. Cell Biol. 126: 331-341.
• Meinck HM, Ricker K, Hulser PJ, Schmid E, Pfeiffer J, Solimena M. 1994. Stiff-man syndrome: clinical and laboratory findings in eight patients. J. Neurol. 241: 157-166.
• Pugliese A, Solimena M, Awdeh Z, Alper C, Bugawan T, Erlich H, De Camilli P, Eisenbarth GS. 1993. Association of HLA-DQB1*0201 with Stiff-Man syndrome. J. Clin.Endocrinol.Metab. 77: 1550-53.
• De Camilli P, Thomas A, Cofiell R, Folli F, Lichte B, Piccolo G, Meinck H-M, Austoni M, Fassetta G, Bottazzo GF, Bates D, Cartlidge N, Solimena M, and Kilimann MW 1993. The synaptic vesicle-associated protein amphiphysin is the autoantigen of Stiff-Man syndrome with breast cancer. J. Exp. Med. 178: 2219-2223.
• Butler M, Solimena M, Dirkx R, Hayday A, De Camilli P. 1993. Identification of a dominant epitope of glutamic acid decarboxylase (GAD65) recognized by autoantibodies in Stiff-Man syndrome. J. Exp. Med. 178: 2097-2106.
• Solimena M, De Camilli P. 1993. Spotlight on a neuronal enzyme. Nature 372: 15-17.
• Solimena M, Aggujaro D, Muntzel C, Dirkx R, Butler M, De Camilli P, Hayday, A. 1993. Association of GAD65, but not of GAD67, with the Golgi complex is mediated by the NH2 terminal region. PNAS USA 90: 3073-3077.
• Folli F, Solimena M, Cofiell R, Austoni M, Tallini G, Fassetta G, Bates D, Cartlidge N, Bottazzo GF, Piccolo G, De Camilli P. 1993. Autoimmunity to a 128kD synaptic protein in three women with the Stiff-man syndrome and breast cancer. New Engl. J. Med. 328: 546-551.
• Reetz A, Solimena M, Matteoli M, Takei K, Folli F, De Camilli P. 1991. GABA and pancreatic ß-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion. EMBO J. 10: 1275-1284.
• Baekkeskov S, Aanstoot H-J, Christgau S, Reetz A, Solimena M, Cascalho M, Folli F, Richter-Olesen H, and De Camilli P. 1990. The 64kd autoantigen of insulin-dependent diabetes mellitus is the GABA synthesizing enzyme glutamic acid decarboxylase. Nature 347: 151-156.
• Solimena M, Folli F, Aparisi, Pozza G, De Camilli P. 1990. Autoantibodies to GABA-ergic neurons and pancreatic ß-cells in Stiff-Man syndrome: a study of 33 cases. New Engl.J. Med. 322: 1555-1560.
• Vicari A, Folli F, Pozza G, Comi G, Comola M, Canal N, Besana C, Borri A, Tresoldi M, Solimena M, De Camilli P. 1989. Plasmapheresis in the treatment of Stiff-Man syndrome. New Engl. J.Med. 320: 1499.
• Solimena M, Folli F, Denis-Donini S, Comi G, Pozza G, De Camilli P, Vicari A. 1988. Autoantibodies directed against glutamic acid decarboxylase (GAD) in the cerebrospinal fluid and serum of a patient with Stiff-Man syndrome, epilepsy and type I diabetes mellitus. New Engl. J. Med. 318: 1012-20.