Benutzerspezifische Werkzeuge

B16: Redirection of immune effector cells to improve engraftment of hematopoietic progenitor cells

Project leader: Prof. Dr. M. Bachmann

 Aggressive myeloablative conditioning prior to allogeneic transplantation of hematopoietic stem cells (HSCs) has severe side effects but is required for an efficient engraftment. Strategies allowing the transplantation without prior intensive conditioning are therefore of great interest. Development of tools for retargeting of immune effector cells to HSCs and other cellular components of the niche (subpopulations of MSCs) may open novel alternative strategies for less harmful conditioning of patients. One major obstacle for an efficient retargeting strategy of HSCs and MSC (sub)populations, however, is their lack of unique single surface markers.

Within this project bispecific antibody components and recently established combinatorial dual-specific retargeting strategies will be developed, functionally established in in vitro assays and adapted for retargeting of HSCs and other cellular components of the niche in in vivo mouse models. This might help us not only to improve our knowledge about the contribution of the respective cellular components of the bone marrow niche but also to identify retargeting conditions and tools translatable into the clinic that can be applied to patients to allow for engraftment without intensive conditioning.

« September 2019 »

Funding program: