Benutzerspezifische Werkzeuge

B11: Factors determining engraftment of transplanted hematopoietic stem cells

Project leader: Prof. Dr. A. Roers

Transplantation of autologous or allogeneic hematopoietic stem cells (HSCs) is an important therapeutic option for neoplasms of the hematopoietic system but is also used to treat primary immunodeficiencies or autoimmune diseases. Even in situations of complete immunological tolerance of the recipient for the transplant, efficient engraftment of transplanted stem cells requires aggressive myelo-ablative pre-conditioning of the recipient, carrying substantial risks. Strategies that would allow transplantation without prior aggressive chemotherapy or irradiation are of great interest. Conflicting reports were published on the role of the number of available empty HSC niches in the recipient bone marrow for the efficiency of engraftment. We have developed a mouse model that allows induced depletion of long-term repopulating HSCs in adult mice and will use this model to clarify whether homing of transplanted HSCs and their long-term engraftment is facilitated in un-irradiated, but HSC-depleted recipients. We will also investigate additional factors which may influence engraftment in HSC-depleted recipients including proinflammatory mediators, oxidative stress and hematopoietic stress. Finally, we will test whether our HSC-depleted mice feature increased receptiveness for xenotransplantation with human HSCs

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Funding program:

DFG