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Gemeinsame Publikationen

A2, A20

Lange C, Huttner WB and Calegari F (2009): Cdk4/cyclinD1 overexpression in mouse neural stem cells shortens G1, delays neurogenesis and promotes the generation and expansion of basal progenitors. Cell stem Cell. 5, 320-31.

 

Attardo A, Calegari F, Haubensak W, Wilsch-Bräuninger M and Huttner WB (2008): Live imaging at the onset of cortical neurogenesis reveals differential appearance of the neuronal phenotype in apical versus basal progenitor progeny. PloS-ONE. 3:6-e2388.

 

De Pietri Tonelli D, Calegari F, Nomura T, Osumi N, Heisenberg C-P and Huttner WB (2006): Single-Cell detection of microRNAs in developing vertebrate embryos after acute administration of a dual fluorescent reporter/sensor plasmid. BioTecniques. 41, 727-732.

 

Calegari F, Haubensak W, Haffner C and Huttner WB (2005): Selective lengthening of the cell cycle in the neurogenic subpopulation of neural progenitor cells during mouse brain development. J Neurosci. 25, 6533-6538.

 

Calegari F and Huttner WB (2003): An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesis. J. Cell. Sci. 116, 4947-4955.

 

 

A2, A20, B5

Calegari F, Marzesco AM, Kittler R, Buchholz F and Huttner WB (2004): Tissue-specific RNA interference in post-implantation mouse embryos using directional electroporation and whole embryo culture. Differentiation. 72, 92-102.

 

Calegari F, Haubensak W, Yang D, Huttner WB and Buchholz F (2002):Tissue-specific RNA interference in postimplantation mouse embryos with endoribonuclease-prepared short interfering RNA. Proc. Natl. Acad. Sci. U. S. A. 99, 14236-14240.

 

   

A2, A21

Attardo A, Fabel K, Krebs J, Haubensak W, Huttner WB and Kempermann G (2010): Tis21 Espression Marks Not Only Populations of Neurogenic Precursor Cells but Also New Postmitotic Neurons in Adult Hippocampal Neurogenesis. Cerebral Cortex. 20, 304-14.

 

 

A2, A6, A23

Chung KF, Sicard F, Vukicevic V, Hermann A, Storch A, Huttner WB, Bornstein SR, Ehrhart-Bornstein M (2009): Isolation of Neural Crest Derived Chromaffin Progenitors from Adult Adrenal Medulla. Stem Cells. 27, 2602-13.

 

 

A2, A3, A4, B3

Jászai J, Fargeas CA, Graupner S, Tanaka EM, Brand M, Huttner WB, Corbeil D (2011): Distinct and Conserved Prominin-1/CD133-Positive Retinal Cell Populations Identified across Species. PLoS One Mar 2;6(3):e17590.

Jászai J, Graupner S, Tanaka EM, Funk RHW, Huttner WB, Brand M, and Corbeil D (2013): Spatial distribution of prominin-1 (CD133)–positive cells within germinative zones of the vertebrate brains. PLoS One 8. e63457.

  

A2, B2, B3

Bauer N, Wilsch-Bräuninger M, Karbanová J, Fonseca A-V, Strauss D, Freund D, Thiele C, Huttner WB, Bornhäuser M and Corbeil D (2011): Hematopoietic stem cell differentiation promotes the release of prominin-1/CD133?containing membrane vesicles ? A role of the endocytic-exocytic pathway. EMBO Mol. Med. 3, 398-409.

 

 

A2, B3

Karbanová, J, Laco J, Marzseco A-M, Janich P, Voborníková M, Mokrý J, Fargeas CA, Huttner WB and Corbeil D. (2014): Human PROMININ-1 (CD133) is detected in both neoplastic and non-neoplastic salivary gland diseases and released into saliva in a ubiquitinated form. PLoS One 9, e9892

Ettinger AW, Wilsch-Bräuninger M, Marzesco AM, Bickle M, Lohmann A, Maliga Z, Karbanová J,  Corbeil D, Hyman AA, Huttner WB . (2011): Proliferating versus differentiating stem and cancer cells exhibit distinct midbody-release behaviour. Nat Commun. 2, 503.  

 

Missol-Kolka E, Karbanová J, Janich P, Haase M, Fargeas CA, Huttner WB and Corbeil D (2011): Prominin-1 (CD133) is not restricted to stem cells located in the basal compartment of murine and human prostate. The Prostate. 71, 254–267.

 

Fietz SA, Kelava I, Vogt J, Wilsch-Bräuninger M, Stezel D, Fish JL, Corbeil D, Riehn A, Distler W, Nitsch R and Huttner WB (2010): Outer subventricular zone progenitors of human and ferret cerebral cortex retain epithelial properties and expand via integrin signaling. Nature Neurosci. 13, 690-699.

Corbeil D, Marzesco A-M, Wilsch-Bräuninger M and Huttner WB (2010): The intriguing links between prominin-1 (CD133), cholesterol-based membrane microdomains, remodeling of apical plasma membrane protrusions, extracellular membrane particles, and (neuro)epithelial cell differentiation. FEBS Lett. 584, 1659-1664.

 

Corbeil D, Marzesco A-M, Fargeas CA and Huttner WB (corresponding author) (2010): Prominin-1, a distinct cholesterol-binding membrane protein and the organisation of the apical plasma membrane of epithelial cells. Subcell Biochem. 51, 399-423.

 

Zacchigna S. Oh H, Wilsch-Bräuninger M, Missol-Kolka E, Jászai J, Jansen S, Tanimoto N, Tonagel F, Seeliger M, Huttner WB, Corbeil D, Dewerchin M, Moons L and Carmeliet P (2009): Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration. J Neurosci. 29, 2297-308.

 

Marzesco A-M, Wilsch-Bräuninger M, Dubreuil V, Janich P, Langenfeld K, Thiele C, Huttner WB and Corbeil D (2009): Release of extracellular membrane vesicles from microvilli of epithelial cells is enhanced by depleting membrane cholesterol. FEBS Lett. 583, 897-902.

 

Corbeil D, Joestr A, Fargeas CA, Jászai J, Garwood J, Hellwig A, Werner HB and Huttner WB (2008): Expression of distinct splice variants of the stem cell marker Prominin-1 (CD133) in glial cells. Glia 57, 860-74.

 

Karbanová J, Missol-Kolka E, Fonseca AV, Lorra C, Janich P, Hollerová H, Jászai J, Ehrmann J, Kolar Z, Liebers C, Arl S, Subrtova D, Freund D, Mokry J, Huttner WB and Corbeil D (2008): The stem cell marker CD133 (prominin-1) is expressed in various human glandular epithelia. J Histochem Cytochem. 56, 977-933.

 

Jászei J, Fargeas CA, Haase M, Farkas LM, Huttner WB and Corbeil D (2008): Robust expression of prominin-2 all along the adult male reproductive system and urinary bladder. Histochem Cell Biol. 130, 749-759.

 

Yang Z, Chen Y, Lillo C, Chien J, Yu Z, Michaelides M, Klein M, Howes KA, Li Y, Kaminoh Y, Chen H, Zhao C, Chen Y, Al-Sheikh YT, Karan G, Corbeil D, Escher P, Kamaya S, Li C, Johnson S, Frederick JM, Zhao Y, Wang C, Cameron DJ, Huttner WB, Schorderet DF, Munier FL, Moore AT, Birch DG, Baehr W, Hunt DM, Williams DS and Zhang K (2008): Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. J Clin Invest. 118, 2908-2916.

 

Lardon J, Corbeil D, Huttner WB, Ling Z and Bouwens L (2008): Stem cell marker prominin 1/AC133 is expressed in duct cells of the adult human pancreas. Pancreas. 36: e1-e6.

 

Jászai J, Janich P, Farkas LM, Fargeas CA, Huttner WB and Corbeil D (2007): Differential expression of prominin-1 (CD133) and prominin-2 in major cephalic  exocrine glands of adult mice. Histochem Cell Biol. 128, 409-419.

 

Jászai J, Fargeas CA, Florek M, Huttner WB and Corbeil D (2007): Focus on Molecules: Prominin-1 (CD133). Exp Eye Res. 85, 585-586.

 

Fargeas CA, Huttner WB and Corbeil D (2007): Nomenclature of pominin-1 (CD133) splice variants – an update. Tissue Antigens. 69, 602-606.

 

Dubreuil V, Marzesco A-M, Corbeil D, Huttner WB and Wilsch-Bräuninger M (2007): Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1. J Cell Biol. 176, 483-495.

 

Fargeas CA, Fonseca A-V, Huttner WB and Corbeil D (2006): Prominin-1 (CD133): from progenitor cells to human diseases. Future Lipidol. 1, 213-225.

 

Kania G, Corbeil D, Fuchs J, Tarasov KV, Blyszeczuk P, Huttner WB, Boheler KR and Wobus AM (2005): The somatic stem cell marker prominin-1/CD133 is expressed in embryonic stem cell-derived progenitors. Stem Cells. 23, 791-804.

 

Lee A, Kessler JD, Read TA, Kaiser C, Corbeil D, Huttner WB, Johnson JE and Wechsler-Reya RJ (2005): Isolation of neural stem cells from the postnatal cerebellum. Nature Neurosci. 8, 723-729.

 

Marzesco A-M, Janich P, Wilsch-Bräuniger M, Dubreuil V, Langenfeld K, Corbeil D and Huttner WB (2005): Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells. J Cell Sci. 118, 2849-2858.

  

A2, B3, B7

Florek M, Bauer N, Janich P, Wilsch-Bräuninger M, Fargeas CA, Marzesco A-M, Ehninger G, Thiele C, Huttner WB and Corbeil D (2007): Prominin-2 is a cholesterol-binding protein associated with apical and basolateral plasmalemmal protrusions in polarized epithelial cells and released into the urine. Cell Tissue Res. 328. 31-47

 

Florek M, Haase M, Marzesco A-M, Freund D, Ehninger G, Huttner WB and Corbeil D (2005): Prominin-1/CD133, a neural and hematopoietic stem cell marker, is expressed in adult human differentiated cels and certain types of kidney cancer. Cell Tissue Res. 319, 15-26.

 

 

A3, NWG

Knopf F, Hammond C, Chekuru A, Kurth T, Hans S, Weber CW, Mahatma G, Fisher S, Brand M, Schulte-Merker S, Weidinger G (2011): Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin. Dev Cell, 20, 713-24.

 

  

A4, NWG

Tanaka EM and Weidinger G (2008): Micromanaging regeneration. Genes & Dev. 22, 700-705.

 

Tanaka EM and Weidinger G (2008). Heads or Tails—Can Wnt tell which one is up? Nat Cell Biol. 10, 122-124.

 

 

A6, A23

Hermann A, List C, Habisch HJ, Vukicevic V, Ehrhart-Bornstein M, Brenner R, Bernstein P, Fickert S, Storch A (2010): Age-dependent neuroectodermal differentiation capacity of human mesenchymal stromal cells: limitations for autologous cell replacement strategies. Cytotherapy. 12, 17-30.

 

 

A6, B3

Sicard F, Ehrhart-Bornstein M, Corbeil D, Sperber S, Krug AW, Ziegler CG, Rettori V, McCann SM, Bornstein SR (2007): Growth factors, DHEA and DHEAS regulate chromaffin cells proliferation in an age-dependent manner. Proc Natl Acad Sci U S A. 104, 2007-2012.

Prewitz M, Seib PF, von Bonin M, Niehae C, Friedrichs J, Stißel A, Müller K, Anastassiadis K, Waskow C, Hoflack B, Bornhäuser M, Werner C. 2013. Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments. Nature Methods. 10:788-794.

A6, B1, B9, B10

Singh RP, Franke K, Kalucka J, Mamlouk S, Mutschter A, Gembarska A, Grinenko T, Willam C, Naumann R, Anastassiadis K, Stewart AF, Bornstein S, Chavakis T, Breier G, Waskow C, Wielockx B. 2013. HIF-prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress. Blood, 121:5158-5166.

A7, B1

Suckale J, Wendling O, Masjkur J, Jäger M, Münster C, Anastassiadis K, Stewart AF, Solimena M (2011): PTBP1 is required for embryonic development before gastrulation. PLoS One 6(2):e16992. PMID: 21423341

 

Liu Y, Suckale J, Masjkur J, Magro MG, Steffen A, Anastassiadis K, Solimena M (2010): Tamoxifen-Independent Recombination in the RIP-CreER Mouse. PLoS One 5(10): e13533. doi:10.1371/journal.pone.0013533.

 

 

A18, B3

Eberle D, Schubert S, Postel K, Corbeil D, Ader M (2011): Increased integration of transplanted CD73-positive photoreceptor precursors into adult mouse retina. Invest Ophthalmol Vis Sci [Epub ahead of print] 

Eberle D, Kurth T, Santos-Ferreira T, Wilson J, Corbeil D, Ader M (2012): Outer segment formation of transplanted photoreceptor precursor cells. PLoS One 7, e46305.

 

A21, B3

Walker TL, Wierick A, Sykes AM, Waldau B, Corbeil D, Carmeliet P, and Kempermann G. (2013): Prominin-1 allows prospective isolation of neural stem cells from the adult murine hippocampus. J Neurosci 33, 3010-3024.

A22, B3

Gurudev N, Florek M, Corbeil D, Knust E. (2013): Prominent Role of Prominin in the Retina. In Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology. Edited by D. Corbeil. Springer Company. Adv Exp Med Biol. In press

A23, B2

Freudenberg U, Hermann A, Welzel PB, Stirl K, Schwarz SC, Grimmer M, Zieris A, Panyanuwat W, Zschoche S, Meinhold D, Storch A, Werner C (2009): A star PEG-heparin hydrogel platform for cell replacement therapies of neurodegenerative diseases. Biomaterials. 30, 5950-8.

 

 

B1, B5

Ding L, Paszkowski-Rogacz M, Nitzsche A, Slabicki MM, Heninger AK, de Vries I, Kittler R, Junqueira M, Shevchenko A, Schulz H, Hubner N, Doss MX, Sachinidis A, Hescheler J, Iacone R, Anastassiadis K, Stewart AF, Pisabarro MT, Caldarelli A, Poser I, Theis M, Buchholz F (2009): A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity. Cell Stem Cell 4, 403-15.

 

Schulz H, Kolde R, Adler P, Aksoy I, Anastassiadis K, Bader M, Billon N, Boeuf H, Bourillot PY, Buchholz F, Dani C, Doss MX, Forrester L, Gitton M, Henrique D, Hescheler J, Himmelbauer H, Hübner N, Karantzali E, Kretsovali A, Lubitz S, Pradier L, Rai M, Raimand J, Rolletschek A, Sachinidis A, Savatier P, Stewart F, Storm MP, Trouillas M, Vilo J, Welham MJ, Winkler J, Wobus AM, Hatzopoulos AK; Functional Genomics in Embryonic Stem Cells Consortium (2009): The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation. PLoS One. 4, e6804.

 

 

B1, NWG

Knopf F 1, Schnabel K 1, Haase C, Pfeifer K, Anastassiadis K, Weidinger G (2010): Dually inducible TetON systems for tissue-specific conditional gene expression in zebrafish. Proc Natl Acad Sci U S A. 107, 19933-8.

1 These authors contributed equally to this work. 

 

B1, B2, B9

Prewitz M, Seib PF, von Bonin M, Niehae C, Friedrichs J, Stißel A, Müller K, Anastassiadis K, Waskow C, Hoflack B, Bornhäuser M, Werner C. 2013. Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments. Nature Methods. 10:788-794.

B2, B3

Niehage C, Steenblock C, Pursche T, Bornhäuser M, Corbeil D, Hoflack B (2011): The cell surface proteome of human mesenchymal stromal cells. PLoS One; 6(5):e20399. Epub 2011 May 26.

 

Fonseca A-V, Freund D, Bornhäuser M and Corbeil D (2010): Polarization and migration of hematopoietic stem and progenitor cells rely on RhoA/ROCK I pathway and an active reorganization of the microtubule network. J. Biol. Chem. 285, 31661-71.

 

Freund D, Fonseca A-V, Janich P, Bornhäuser M and Corbeil D (2010): Differential expression of biofunctional GM1 and GM3 gangliosides within the plastic-adherent multipotent mesenchymal stromal cell population. Cytotherapy. 12, 131-42.

 

Bauer N, Fonseca A-V, Florek M, Freund D, Jászai J, Bornhäuser M, Fargeas CA and Corbeil D (2008): New insights into the cell biology of hematopoietic progenitors by studying prominin-1 (CD133). Cells Tissues Organs. 188, 127-138.

 

Bauer N, Fonseca AV, Florek M, Freund D, Jászai J, Bornhäuser M, Fargeas CA, Corbeil D (2007): New insights into the cell biology of hematopoietic progenitors by studying Prominin-1 (CD133). Cells Tissues Organs. 188, 127-138.

 

 

B2, B6

Jacobi A, Thieme S, Lehmann R, Ugarte F, Malech HL, Koch S, Thiede C, Muller K, Bornhauser M, Ryser M, Brenner S (2010): Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts. Exp. Hematol. 38, 180-190.

 

Ryser MF, Thieme S, Bornhäuser M, Lehmann R, Brenner S (2009): Serum albumin strongly influences SDF-1 dependent migration. Int J Hematol. 89, 269-75.

 

Ryser MF, Ugarte F, Thieme S, Bornhäuser M, Roesen-Wolff A, Brenner S (2008): mRNA Transfection of CXCR4-GFP Fusion-Simply Generated by PCR-Results in Efficient Migration of Primary Human Mesenchymal Stem Cells. Tissue Eng Part C. Methods. 14, 179-184.

 

Ryser MF, Ugarte F, Gentsch M, Lehmann R, Bornhäuser M, Brenner S (2008): S1P1 overexpression stimulates S1P dependent chemotaxis oh human hematopoietic stem cells but strongly inhibits SDF-1/CXCR4 dependent migration an in vivo homing. Mol Immunol. 46, 166-71.

 

Kroschinsky F, Hölig K, Platzbecker U, Poppe-Thiede K, Ordemann R, Blechschmidt M, Oelschlaegel U, Schaich M, Hänel M, Bornhäuser M, Ehninger G (2006): Efficacy of single-dose pegfilgrastim after chemotherapy fort he mobilization of autologous peripheral blood stem cells in patients with malignant lymphoma or multiple myeloma. Transfusion. 46, 1417-1423.

 

 

B2, B7

Ovcharenko D, Stölzel F, Poitz D, Fierro F, Schaich M, Neubauer A, Kelnar K, Davison T, Müller-Tidow C, Thiede C, Bornhäuser M, Ehninger G, Brown D, Illmer T (2011): miR-10a Overexpression is Associated with NPM1 Mutations and Mdm4 Downregulation in Intermediate-Risk Acute Myeloid Leukemia. Exp Hematol. 2011 Jul 21. [Epub ahead of print]

 

Jing D, Alakel N, Bornhäuser M, Ehninger G, Ordemann R (2010): SDF-1/CXCR4 blockade to mobilize hematopoietic progenitor cells from the placenta. Bone Marrow Transplant 45,1661-2.

 

Jing D, Oelschlaegel U, Ordemann R, Holig K, Ehninger G, Reichmann H, Ziemssen T, Bornhäuser M (2010): CD49d blockade by natalizumab in patients with multiple sclerosis affects steady-state hematopoiesis and mobilizes progenitors with a distinct phenotype and function. Bone Marrow Transplant. 45, 1489-96.

 

Fierro FA, Taubenberger A, Puech PH, Ehninger G, Bornhäuser M, Muller DJ, Illmer T (2008): BCR/ABL expression of myeloid progenitors increases beta1-integrin mediated adhesion to stromal cells. J. Mol. Biol. 377, 1082-1093.

 

Platzbecker U, Bornhäuser M, Germing U, Stumpf J, Scott BL, Kroger N, Schwerdtfeger R, Bohm A, Kobbe G, Theuser C, Rabitsch W, Valent P, Sorror ML, Ehninger G, Deeg HJ (2008): Red blood cell transfusion dependence and outcome after allogeneic peripheral blood stem cell transplantation in patients with de novo myelodysplastic syndrome (MDS). Biol. Blood Marrow Transplant. 14, 1217-1225.

 

von Bonin M, Oelschlägel U, Radke J, Stewart M, Ehninger G, Bornhäuser M, Platzbecker U (2008): Treatment of chronic steroid-refractory graft-versus-host disease with low-dose rituximab. Transplantation. 86, 875-879.

 

Schetelig J, Bornhäuser M, Schmid C, Hertenstein B, Schwerdtfeger R, Martin H, Stelljes M, Hegenbart U, Schafer-Eckart K, Fussel M, Wiedemann B, Thiede C, Kienast J, Baurmann H, Ganser A, Kolb HJ, Ehninger G (2008): Matched unrelated or matched sibling donors result in comparable survival after allogeneic stem-cell transplantation in elderly patients with acute myeloid leukemia: a report from the kooperative German Transplant Study Group. J. Clin. Oncol. 26, 5183-5191.

 

Platzbecker U, Binder M, Schmid C, Rutt C, Ehninger G, Bornhäuser M (2008): Second donation of hematopoietic stem cells from unrelated donors for patients with relapse or graft failure after allogeneic transplantation. Haematologica. 93, 1276-1278.

 

Schulze A, Schirutschke H, Oelschlägel U, Schmitz M, Fussel M, Wassmuth R, Ehninger G, Bornhäuser M, Platzbecker U (2008): Altered phenotype of natural killer cell subsets after haploientical stem cell transplantation. Exp. Hematol. 36, 378-389.

 

Platzbecker U, Stoehlmacher J, Pabst C, Goekkurt E, Oelschlaegel U, Schirutschke H, Hölig K, Theuser C, Mogck U, Ehninger G, Bornhäuser M (2008): Induction of Toll-like receptor 2 and 4 expression on CD4+ and CD8+ T cells in G-CSF-mobilized unrelated peripheral blood stem cell grafts during leukapheresis: impact on patient outcome. Leukemia. 22, 1438-1440.

 

Fierro F, Illmer T, Jing D, Schleyer E, Ehninger G, Boxberger S, Bornhäuser M (2007): Inhibition of platelet-derived growth factor receptor-β by Imatinib mesylate suppresses proliferation and alters differentiation of human mesenchymal stem cells in vitro. Cell Prolif. 40, 355-366.

 

Schmid C, Labopin M, Nagler A, Bornhäuser M, Finke J, Fassas A, Volin L, Gurman G, Maertens J, Bordigoni P, Holler E, Ehninger G, Polge E, Gorin NC, Kolb HJ, Rocha V (2007): Donor lymphocyte infusion in the treatment of first hematological relapse after allogeneic stem-cell transplantation in adults with acute myeloid leukemia: a retrospective risk factors analysis and comparison with other strategies by the EBMT Acute Leukemia Working Party. J. Clin. Oncol. 25, 4938-4945.

 

Platzbecker U, Mohr B, von Bonin M, Binder M, Schetelig J, Ehninger G, Bornhäuser M (2007): Lenalidomide as induction therapy before allogeneic stem cell transplantation in a patient with proliferative CMML-2 and del(5q) not involving the EGR1 locus. Leukemia. 21, 2384-2385.

 

Pabst C, Schirutschke H, Ehninger G, Bornhäuser M, Platzbecker U (2007): The graft content of donor T cells expressing gamma delta TCR+ and CD4+foxp3+predicts the risk of acute graft versus host disease after transplantation of allogeneic peripheral blood stem cells from unrelated donors. Clin. Cancer Res. 13, 2916-2922.

 

Auffermann-Gretzinger S, Eger L, Schetelig J, Bornhäuser M, Heidenreich F, Ehninger G (2007): Alemtuzumab depletes dendritic cells more effectively in blood than in skin: a pilot study in patients with chronic lymphocytic leukemia. Transplantation. 83,1268-1272.

 

Oelschlaegel U, Bornhäuser M, Boxberger S, Kroschinsky F, Illmer T, Hoelig K, Calandra G, Ehninger G, Platzbecker U (2007): Kinetics of CXCR-4 and adhesion molecule expression during autologous stem cell mobilisation with G-CSF plus AMD3100 in patients with multiple myeloma. Ann. Hematol. 86, 569-573.

 

Oswald J, Steudel C, Salchert K, Joergensen B, Thiede C, Ehninger G, Werner C, Bornhäuser M (2006): Gene expression profiling of CD34+ hematopoietic cells expanded in a collagen I matrix. Stem Cells. 24, 494-500.

 

Auffermann-Gretzinger S, Eger L, Bornhäuser M, Schäkel K, Oelschlaegel U, Schaich M, Illmer T, Thiede C, Ehninger G (2006): Fast appearance of donor dendritic cells in human skin: dynamics of skin and blood dendritic cells after allogeneic hematopoietic cell transplantation. Transplantation. 81, 866-873.

 

Platzbecker U, Thiede C, Fussel M, Geissler G, Illmer T, Mohr B, Hänel M, Mahlberg R, Krumpelmann U, Weissinger F, Schaich M, Theuser C, Ehninger G, Bornhäuser M (2006): Reduced intensity conditioning allows for up-front allogeneic hematopoietic stem cell transplantation after cytoreductive induction therapy in newly-diagnosed high-risk acute myeloid leukemia. Leukemia. 20, 707-714.

 

Kroschinsky F, Hölig K, Poppe-Thiede K, Zimmer K, Ordemann R, Blechschmidt M, Oelschlaegel U, Bornhäuser M, Rall G, Rutt C, Ehninger G (2005): Single-dose pegfilgrastim fort he mobilization of allogeneic CD34+ peripheral blood progenitor cells in healthy family and unrelated donors. Haematologica. 90, 1665-1671.

 

Strodtbeck D, Bornhäuser M, Hänel M, Lerche L, Schaich M, Illmer T, Thiede C, Geissler G, Herbst R, Ehninger G, Platzbecker U (2005): Graft clonogenicity and intensity of pre-treatment: factors affecting outcome of autologous peripheral hematopoietic cell transplantation in patients with acute myeloid leukemia in first remission. Bone Marrow Transplant. 36, 1083-1088.

 

  

B2, B7, B8

Von Bonin M, Stölzel F, Goedecke A, Richter A, Wuschek N, Hölig K, Platzbecker U, Illmer T, Schaich M, Kiani A, Schetelig J, Ordemann R, Ehninger G, Schmitz M, Bornhäuser M (2008): Treatment of refractory acute GVHD with third party MSC expanded in platelet lysate containing medium. Bone Marrow Transplant. 43, 245-51.

 

Bornhäuser M, Illmer T, Oelschlägel U, Schetelig J, Ordemann R, Schaich M, Hanel M, Schuler U, Thiede C, Kiani A, Platzbecker U, Ehninger G (2008): Gemtuzumab ozogamicin as part of reduced-intensity conditioning for allogeneic hematopoietic cell transplantation in patients with relapsed acute myeloid leukemia. Clin. Cancer Res. 14, 5585-5593.

 

Haentzschel I, Freiberg-Richter J, Platzbecker U, Kiani A, Schetelig J, Illmer T, Ehninger G, Schleyer E, Bornhäuser M (2008): Targeting mycophenolate mofetil for graft-versus-host disease prophylaxis after allogeneic blood stem cell transplantation. Bone Marrow Transplant. 42, 113-120.

 

Kiani A, Kuithan H, Kuithan F, Kyttala S, Habermann I, Temme A, Bornhäuser M, Ehninger G (2007): Expression analysis of nuclear factor of activated T cells (NFAT) during myeloid differentiation of CD34+ cells: regulation of Fas ligand gene expression in megakaryocytes. Exp. Hematol. 35, 757-770

 

Bornhäuser M, Thiede C, Babatz J, Schetelig J, Illmer T, Kiani A, Platzbecker U, Herr W, Rieber EP, Ehninger G, Schmitz M (2006): Infusion of bcr/abl peptide-reactive donor T cells to achieve molecular remission of chronic myeloid leukemia after CD34+ selected allogeneic hematopoietic cell transplantation. Leukemia. 20, 2055-2057.

 

Schetelig J, Kiani A, Schmitz M, Ehninger G, Bornhäuser M (2005): T cell-mediated graft-versus-leukemia reactions after allogeneic stem cell transplantation. Cancer Immunol. Immunother. 54, 1043-1058.

 

Kiani A, Habermann I, Haase M, Feldmann S, Boxberger S, Sanchez-Fernandes Maria A, Thiede C, Bornhäuser M, Ehninger G (2004): Expression and Regulation of NFAT (Nuclear Factors of Activated T cells) in Human Cd34+ Cells: Downregulation Upon Myeloid Differentiation. Journal of Leukocyte Biology. 76 (5): 1057-1065.

 

  

B2, B3, B7

Jing D, Fonseca A-V, Alakel N, Fierro FA, Müller K, Bornhäuser M, Ehninger G, Corbeil D and Ordemann R (2010): Hematopoietic stem cells in coculture with mesenchymal stromal cells – modelling the niche compartments in-vitro. Haematologica. 95, 542-550.

 

Freund D, Bauer N, Boxberger S, Feldmann S, Streller U, Ehninger G, Werner C, Bornhäuser M, Oswald J, Corbeil D (2006): Polarization of human hematopoietic progenitors during contact with multipotent mesenchymal stromal cells: effects on proliferation and clonogenicity. Stem Cells Dev. 15, 815-829.

 

Freund D, Oswald J, Feldmann S, Ehninger G, Corbeil D and Bornhäuser M (2006): Comparative analysis of proliferative potential  and clonogenicity of MACS-immunomagnetic isolated CD34+ and CD133+ blood stem cells derived from a single donor . Cell Prolif. 39, 325-332.

B2, B9

Cosgun* KN, Rahmig* S, Mende N, Reinke S, Hauber I, Schäfer C, Petzold A, Weisbach H, Heidkamp G, Purbojo A, Cesnjevar R, Platz A, Bornhäuser M, Schmitz M, Dudziak D, Hauber J, Kirberg J, Waskow C, 2014. Kit Regulates HSC Engraftment across the Human-Mouse Species Barrier. Cell Stem Cell, in press, http://dx.doi.org/10.1016/j.stem.2014.06.001.   *Co-first authors.

Von Bonin M, Wermke M, Cosgun KN, Thiede C, Bornhauser M, Wagemaker G, Waskow C. 2013 In vivo expansion of co-transplanted T cells impacts on tumor re-initiating activity of human acute myeloid leukemis in NSG mice. PLoS One. 8:e60680. Doi: 10.1371.

 

B2, B3, B7, B8

Bornhäuser M, Eger L, Oelschlaegel U, Auffermann-Gretzinger S, Kiani A, Schetelig J, Illmer T, Schaich M, Corbeil D, Thiede C, Ehninger G (2005): Rapid reconstitution of dendritic cells after allogeneic transplantation of CD133+ selected hematopoietic stem cells. Leukemia. 19, 161-165.

 

 

B2, B6, B7

Fierro FA, Brenner S, Oelschlaegel U, Jacobi A, Knoth H, Ehninger G, Illmer T, Bornhäuser M (2009): Combining SDF-1/CXCR4 antagonism and chemotherapy in relapsed acute myeloid leukemia. Leukemia 23, 393-6. Epub 2008 Jul 10.

 

B3, B9

Arndt K, Grinenko T, Mende N, Reichert D, Portz M, Ripich T, Carmeliet P, Corbeil D , and Waskow C (2013): CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells. Proc Natl Acad Sci USA 110, 5582-5587.

B5, B9

Ross K, Sedello AK, Todd GP, Paszkowski-Rogacz M, Bird AW, Ding L, Grinenko T, Behrens K, Hubner N, Mann M, Waskow C, Stocking C, and Buchholz F. 2012. Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells. Blood 119:4152-4161. 

B7, B8

Kyttälä S, Habermann I, Minami T, Ehninger G, Kiani A (2009): Regulation of Down Syndrome Critical Region 1 (DSCR1) Expression by Nuclear Factor of Activated T cells (NFAT) in Megakaryocytes. British Journal of Haematology. 144 (3), 395-408.

Projektgruppen in Zusammenarbeit mit der Deep sequencing facility

Grinenko T, Arndt K, Portz M, Mende N, Günther M, Cosgun KN, Alexopoulou D, Lakshmanaperumal N, Henry I, Dahl A, Waskow C, 2014. Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cells. J Exp Med. 211:209-215.

 

Kizil C*, Dudczig S*, Kyritsis N, Machate A, Blaesche J, Kroehne V, Brand M. (2012a). The chemokine receptor cxcr5 regulates the regenerative neurogenesis response in the adult zebrafish brain. Neural Dev. 7:27. * equal contribution. „Highly accessed“ article.

Kizil C, Kyritsis N, Dudczig S, Kroehne V, Freudenreich D, Kaslin J, Brand M (2012b). Regenerative neurogenesis from neural progenitor cells requires injury-induced expression of Gata3. Dev Cell 23, 1-8, DOI 10.1016/j.devcel.2012.10.014.
Kyritsis N, Kizil C, Zocher S, Kroehne V, Kaslin J, Freudenreich D, Iltzsche A, Brand M (2012). Acute inflammation initiates the regenerative response in the adult zebrafish brain. Science, Nov 8, DOI 10.1126.science.1228773.

Thieme S, Gyárfás T, Richter C, Özhan-Kizil G, Fu J, Alexopoulou D, Muders MH, Michalk I, Jakob C, Dahl A, Klink B, Bandola J, Bachmann M, Schröck E, Buchholz F, Stewart AF, Weidinger G, Anastassiadis K, and Brenner S (2012): The histone demethylase UTX regulates stem cell migration and hematopoiesis. Blood in press.

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Funding program:

DFG