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B6: SFB-relevante Publikationen

Ortlepp C, Steudel C, Heiderich C, Koch S, Jacobi A, Ryser M, Brenner S, Bornhäuser M, Brors B, Hofmann W-K, Ehninger G, Thiede C (2013). Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation. Exp Hem. in press

Thieme S, Gyárfás T, Richter C, Özhan G, Fu J, Alexopoulou D, Muders MH, Michalk I, Jakob C, Dahl A, Klink B, Bandoła J, Bachmann M, Schröck E, Buchholz F, Stewart AF, Weidinger G, Anastassiadis K, Brenner S (2012): The histone demethylase UTX regulates stem cell migration and hematopoiesis. Blood, in press.

Stopp S, Bornhäuser M, Ugarte F, Wobus M, Kuhn M, Thieme S, Brenner S (2012): Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells. Haematol epub ahead. PMID:22801967, in press.

Hofmann SR, Möller J, Rauen T, Paul D, Gahr M, Rösen-Wolff Z, Brenner S, Hedrich CM. (2012): Dynamic CpG-DNA methylation of Il10 and Il19 in CD4+ T lymphocytes and macrophages: effects on tissue-specific gene expression. Klin Padiatr. 224(2):53-60

Jacobi A, Thieme S, Lehmann R, Ugarte F, Malech HL, Koch S, Thiede C, Müller K, Bornhäuser M, Ryser M, Brenner S. Impact of CXCR4 inhibition on FLT3-ITD positive human AML blasts. Exp Hematol. 2010;38:180-190.

Ugarte F, Ryser M, Thieme S, Fierro FA, Navratiel K, Bornhäuser M, Brenner S. Notch signaling enhances osteogenic differentiation while inhibiting adipogenesis in primary human bone marrow stromal cells. Exp Hematol. 2009 Jul;37(7):867-875.

Ryser MF, Thieme S, Bornhäuser M, Lehmann R, Brenner S (2009): Serum albumin strongly influences SDF-1 dependent migration. Int J Hematol. 89, 269-75.

Thieme S, Ryser M, Gentsch M, Brenner S, Stiehler M, Rölfing J, Gelinsky M, Rösen-Wolff A. Stromal derived factor-1a (SDF-1α) directed chemoattraction of transiently CXCR4 overexpressing mesenchymal stem cells into functionalised three-dimensional biomimetic scaffolds. Tissue Eng. 2009 Dec;15(4):687-96.

Fierro FA, Brenner S, Oelschlaegel U, Jacobi A, Knoth H, Ehninger G, Illmer T, Bornhäuser M (2009): Combining SDF-1/CXCR4 antagonism and chemotherapy in relapsed acute myeloid leukemia. Leukemia 23, 393-6. Epub 2008 Jul 10.

Moreno-Carranza B, Gentsch M, Stein S, Schambach A, Santilli G, Rudolf E, Ryser MF, Haria S, Thrasher AJ, Baum C, Brenner S, Grez M (2009) Transgene optimization significantly improves SIN vector titers, gp91phox expression and reconstitution of superoxide production in X-CGD cells. Gene Ther. 16, 111-8. Epub 2008 Sep 11.

Ryser MF, Ugarte F, Thieme S, Gentsch M, Bornhäuser M, Roesen-Wolff A, Brenner S (2008a). mRNA transfection of a CXCR4-GFP fusion protein - generated by a simple three step PCR protocol - results in efficient migration of primary mesenchymal stem cells. Tissue Eng Part C Methods.14, 179-84.

Ryser MF, Ugarte F, Gentsch M, Lehmann R, Bornhäuser M, Brenner S (2008b): S1P1 overexpression stimulates S1P dependent chemotaxis of human hematopoietic stem cells but strongly inhibits SDF-1/CXCR4 dependent migration and in vivo homing. Mol Immunol. 46, 166-71.

Brenner S, Ryser MF, Whiting-Theobald NL, Gentsch M, Linton GF, Malech HL (2007): The late dividing population of gamma-retroviral vector transduced human mobilized peripheral blood progenitor cells contributes most to gene-marked cell engraftment in nonobese diabetic/severe combined immunodeficient mice. Stem Cells. 25, 1807-13.

Brenner S, Ryser MF, Choi U, Whiting-Theobald N, Kuhlisch E, Linton G, Kang E, Lehmann R, Rosen-Wolff A, Rudikoff AG, Farese AM, MacVittie TJ, Roesler J, Horwitz ME, Malech HL (2006): Polyclonal long-term MFGS-gp91phox marking in rhesus macaques after non-myeloablative transplantation with transduced autologous peripheral blood progenitor cells. Mol Ther. 14, 202-11.

Ueda T, Brenner S, Malech HL, Langemeijer SM, Perl S, Kirby M, Phang OA, Krouse AE, Donahue RE, Kang EM, Tisdale JF (2005). Cloning and functional analysis of the rhesus macaque ABCG2 gene. Forced expression confers an SP phenotype among hematopoietic stem cell progeny in vivo. J Biol Chem. 280, 991-8.

Brenner S, Whiting-Theobald N, Kawai T, Linton GF, Rudikoff AG, Choi U, Ryser MF, Murphy PM, Sechler JM, Malech HL. CXCR4-transgene expression significantly improves marrow engraftment of cultured hematopoietic stem cells. Stem Cells. 2004;22(7):1128-33.

Brenner S, Whiting-Theobald NL, Linton GF, Holmes KL, Anderson-Cohen M, Kelly PF, Vanin EF, Pilon AM, Bodine DM, Horwitz ME, Malech HL. Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/beta -microglobulin-/- repopulating mobilized human peripheral blood CD34+ cells. Blood. 2003 Oct 15;102(8):2789-97.

 

 

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Funding program:

DFG