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Rotationsprojekt 3

Projektleiter:  

Alexander Jarosch
Assistenzarzt / Wissenschaftlicher Mitarbeiter
Klinik und Poliklinik für Neurologie
Universitätsklinikum Carl Gustav Carus
der Technischen Universität Dresden
Fetscherstraße 74
01307 Dresden

Projekttitel:    Adult neural stem cell plasticity in a chronic lesion model for Parkinson's disease in the regenerating CNS of the zebrafish 
Beteiligte SFB-Mitglieder:
(Co-Leiter)
 

Prof. Dr. Michael Brand
DFG-Forschungszentrum und Exzellenzcluster
für Regenerative Therapien Dresden (CRTD) und
BIOTEC, Biotechnologisches Center
Technische Universität Dresden
SFB-Teilprojekt A3

Prof. Dr. Alexander Storch
Klinik und Poliklinik für Neurologie
Universitätsklinikum Carl Gustav Carus
der Technischen Universität Dresden
SFB-Teilprojekt A23 

Förderzeitraum:   1. Oktober 2009 - 30. September 2010
Zusammenfassung:  

The capacity to generate new neurons is lost in the most areas of the adult mammalian brain, while most non-mammalian vertebrates, including teleosts, retain this ability in many areas of the CNS. Mechanisms of neurogenesis are generally highly conserved among vertebrates.

However, the mechanisms that support neural precursor /stem cell activity in the teleost brain, or that prevent it in the mammalian brain, are at present largely unkown. Identification and better understanding of these mechanisms is important to develop strategies for reactivating neural development in the senescing brain. In this Gerok rotation project, we establish neuronal tissue culture systems for neurons derived from adult brain, and characterise the growth requirements and ability of the cells to differentiate.

Furthermore, based on a previously isolated zebrafish homologue of a human risk gene for Parkinson's disease, we have generated a null allele in this gene and compare the phenotype and growth conditions of null mutant cells in the newly established tissue culture system.

The results should contribute to better understanding of the neurodegenerative mechanisms that are operating in Parkinson's disease, and the response of adult neural stem cells to chronic lesions in this disease in the vertebrate brain.

Relevante Publikationen:  
  1. Ganz J., Kaslin J., Hochmann S., Freudenreich D., Brand M. (2010): Heterogeneity and Fgf dependence of adult neural progenitors in the zebrafish telencephalon. GLIA, 58(11):1345-1363.

  2. Brandt MD, Maass A, Kempermann G, Storch A (2010): Physical exercise increases Notch activity, proliferation and cell cycle exit of type-3 progenitor cells in adult hippocampal neurogenesis. Eur J Neurosci. 2010 Oct;32(8):1256-64.

 

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Funding program:

DFG